Researchers Explain Role of Nervous System in Asthma – Headlines & Global News


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Researchers Explain Role of Nervous System in Asthma
Headlines & Global News
The condition can be fatal and during an asthma attack airways tighten even further in the presence of a trigger, such as pollen, dust mites or a viral infection. The present therapies treat asthma attacks as immune responses and focus on immune system …
Nervous System's Role In Asthma Attacks RevealedCounsel & Heal
Sensory Neurons Control Bronchial ActivityScience World Report

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Does ?-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of ?-Hexosaminidase in Mast Cell Granules.

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Does ?-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of ?-Hexosaminidase in Mast Cell Granules.

J Immunol. 2014 Jul 11;

Authors: Fukuishi N, Murakami S, Ohno A, Yamanaka N, Matsui N, Fukutsuji K, Yamada S, Itoh K, Akagi M

Abstract
?-Hexosaminidase, which is generally present in the lysosome, is essential for glycoprotein metabolism in the maintenance of cell homeostasis. In mast cells (MCs), large amounts of ?-hexosaminidase are present in the granules as opposed to the lysosome, and the biological role of MC ?-hexosaminidase has yet to be fully elucidated. Therefore, we investigated the biological role of ?-hexosaminidase in MC granules. Bone marrow-derived MCs from C57BL/6 (BL/6-BMMC) or ?-hexosaminidase gene-deficient (hexb(-/-)-BMMC) mice were transplanted into MC-deficient (WBB6F1/J-Kit(W)/Kit(W-v) [W/W(v)]) mice to generate MC-reconstituted models. In asthma model experiments, no differences were observed in the symptoms of BL/6, W/W(v), BL/6-BMMC-reconstituted W/W(v), or hexb(-/-)-BMMC-reconstituted W/W(v) mice. In Staphylococcus epidermidis experimental infection model experiments, the severity of symptoms and frequency of death were markedly higher in W/W(v) and hexb(-/-)-BMMC-reconstituted W/W(v) mice than in BL/6 and BL/6-BMMC-reconstituted W/W(v) mice. The growth of S. epidermidis in an in vitro study was clearly inhibited by addition of BL/6-BMMC lysate, but not by addition of hexb(-/-)-BMMC lysate. Moreover, suppression of bacterial proliferation was completely recovered when bacteria were incubated with hexb(-/-)-BMMC lysate plus ?-hexosaminidase. Transmission electron microscopy indicated that the cell wall of S. epidermidis was heavily degraded following coincubation of bacteria with BL/6-BMMC lysate, but not following coincubation with hexb(-/-)-BMMC lysate. These findings strongly suggest that MC granule ?-hexosaminidase is crucial for defense against bacterial invasion, but is not involved in the allergic response. Our results also suggest that the bactericidal mechanism of ?-hexosaminidase involves degradation of bacterial cell wall peptidoglycan.

PMID: 25015817 [PubMed – as supplied by publisher]

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Study questions role of vitamin D in asthma – Reuters


Bioscience Technology

Study questions role of vitamin D in asthma
Reuters
“Our thought was that vitamin D would potentially make . . . the standard therapy, inhaled corticosteroids, work better in these patients, and that it would reduce their asthma exacerbations,” he told Reuters Health. To test that theory, the
Asthma: vitamin D supplements 'do not improve symptoms or treatment'Medical News Today
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Study questions role of vitamin D in asthma – Business Insider


Laboratory Equipment

Study questions role of vitamin D in asthma
Business Insider
NEW YORK (Reuters Health) – Giving people with asthma and low vitamin D levels extra doses of the vitamin doesn't do much to help their lungs, a new study suggests. Previous research had linked low vitamin D levels to more asthma-related problems, like …
Asthma: vitamin D supplements 'do not improve symptoms or treatment'Medical News Today
Vitamin D has Little Benefit as Asthma TreatmentLaboratory Equipment
Vitamin D Supplements May Not Help Ease AsthmaHealthDay
Authint Mail
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Asthma may play a role in bone density loss – KSBY San Luis Obispo News


Times of India

Asthma may play a role in bone density loss
KSBY San Luis Obispo News
Data from more than 70,000 people shows lower bone density among patients with airway problems or asthma. Prior research has shown that steroids used to treat breathing conditions can impact bone health, but experts say it also appears asthma itself is
Study finds asthma is associated with decrease in bone mineral densityNews-Medical.net
Asthma may lead to bone lossTimes of India
Asthma sufferers may be prone to bone lossBusiness Standard

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Specific protein has vital role in controlling symptoms of allergic asthma … – News-Medical.net

Specific protein has vital role in controlling symptoms of allergic asthma
News-Medical.net
An enzyme that helps maintain immune system function by "throwing away" a specific protein has a vital role in controlling symptoms of allergic asthma, new research in mice suggests. The finding suggests that this enzyme, called Cbl-b, could be a
Researchers find potential target for drug to treat allergic asthmaScience Codex

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