Early mold exposure may play role in asthma development – Pediatric SuperSite


Press TV

Early mold exposure may play role in asthma development
Pediatric SuperSite
Early life exposure to mold may play a role in childhood asthma development, according to a study published online. Tiina Reponen, PhD, professor of environmental health at the University of Cincinnati, and colleagues analyzed 7 years of data for 176
Mold exposure in infancy raises asthmaPress TV

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The role of bacteria in asthma and the potential for antibiotic treatment – EurekAlert (press release)

The role of bacteria in asthma and the potential for antibiotic treatment
EurekAlert (press release)
NEW ORLEANS, LA – May 23, 2011 — People with severe asthma are more likely to have antibodies against the disease-causing bacteria Chlamydia pneumoniae than the general population and in some cases antibiotic treatment can greatly improve symptoms

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Sunshine plays vital role in protecting kids from asthma – Daily News & Analysis


Eureka! Science News

Sunshine plays vital role in protecting kids from asthma
Daily News & Analysis
A new study led by Valencian researchers has shown that children who live in colder, wetter cities are at greater risk of suffering from asthma, since there are fewer hours of sunlight in such places. "Prolonged exposure to the sun can cause cancer,
Vitamin D plays key role in protection against childhood asthmaNews-Medical.net

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Family mealtimes play a role in health of children with asthma – The Virtual Medical Centre


The Virtual Medical Centre

Family mealtimes play a role in health of children with asthma
The Virtual Medical Centre
Now, a new study that looks at children with asthma has found that the quality of family interactions during mealtime affected the children's health. The study appears in the January/February issue of the journal Child Development.

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Family Mealtimes Play a Role in the Health of Children with Asthma – news Stories


Telegraph.co.uk

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Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells.

Molecular expression and functional role of canonical transient receptor potential channels in airway smooth muscle cells.

Adv Exp Med Biol. 2011;704:731-47

Authors: Wang YX, Zheng YM

Multiple canonical or classic transient receptor potential (TRPC) molecules are expressed in animal and human airway smooth muscle cells (SMCs). TRPC3, but not TRPC1, is a major molecular component of native non-selective cation channels (NSCCs) to contribute to the resting [Ca(2+)](i) and muscarinic increase in [Ca(2+)](i) in freshly isolated airway SMCs. TRPC3-encoded NSCCs are significantly increased in expression and activity in airway SMCs from ovalbumin-sensitized/challenged “asthmatic” mice, whereas TRPC1-encoded channel activity, but not its expression, is largely augmented. The upregulated TRPC3- and TRPC1-encoded NSCC activity both mediate “asthmatic” membrane depolarization in airway SMCs. Supportively, tumor necrosis factor-? (TNF?), an important asthma mediator, increases TRPC3 expression, and TRPC3 gene silencing inhibits TNF?-mediated augmentation of acetylcholine-evoked increase in [Ca(2+)](i) in passaged airway SMCs. In contrast, TRPC6 gene silencing has no effect on 1-oleoyl-2-acetyl-sn-glycerol (OAG)-evoked increase in [Ca(2+)](i) in primary isolated cells. These findings provide compelling information indicating that TRPC3-encoded NSCCs are important for physiological and pathological cellular responses in airway SMCs. However, continual studies are necessary to further determine whether, which, and how TRPC-encoded channels are involved in cellular responses in normal and diseased (e.g., asthmatic) airway SMCs.

PMID: 21290324 [PubMed – in process]

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