Tag: Study

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Study on the Treatment of Bronchial Asthma With Traditional Chinese Medicine

Condition:   Bronchial Asthma
Interventions:   Drug: Ke Chuan Liu Wei Mixture;   Drug: Chuan Xiong Ping Chuan Mixture;   Drug: Xie Wu Capsule;   Drug: Dan Ma Jia Tablet;   Drug: Zhi Chuan Capsule;   Drug: Bu Shen Na Qi Granule;   Drug: Ke Chuan Liu Wei Mixture placebo;   Drug: Chuan Xiong Ping Chuan Mixture placebo;   Drug: Xie Wu Capsule placebo;   Drug: Dan Ma Jia Tablet placebo;   Drug: Zhi Chuan Capsule placebo;   Drug: Bu Shen Na Qi Granule placebo
Sponsor:   Shanghai University of Traditional Chinese Medicine
Not yet recruiting – verified October 2016

View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days

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A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics (PK) After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers.

Condition:   Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Treatment A – AZD7594;   Drug: Treatment B – AZD7594;   Drug: Treatment C – AZD7594
Sponsor:   AstraZeneca
Not yet recruiting – verified October 2016

View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days

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A Study to Assess the Effect of Particle Size of AZD7594 on Pharmacokinetics After a Single Inhaled Dose When Administered Using the Dry Powder Inhaler in Healthy Volunteers.

Condition:   Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Interventions:   Drug: Treatment A – AZD7594;   Drug: Treatment B – AZD7594;   Drug: Treatment C – AZD7594
Sponsor:   AstraZeneca
Not yet recruiting – verified October 2016

View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days

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A 12-week, Randomized, Parallel-Group, Proof-of-Concept Study of Tulobuterol Patch and Salmeterol Inhaler as Add-on Therapy in Adult-Onset Mild-to-Moderate Asthma.

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A 12-week, Randomized, Parallel-Group, Proof-of-Concept Study of Tulobuterol Patch and Salmeterol Inhaler as Add-on Therapy in Adult-Onset Mild-to-Moderate Asthma.

Clin Exp Pharmacol Physiol. 2016 Oct 8;:

Authors: Inoue H, Niimi A, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Mishima M

Abstract
Patch formulation of tulobuterol has been used in asthma treatment as a long-acting ?2 -agonist (LABA) through sustained skin absorption. Its treatment efficacy, especially in small airways, remains poorly understood. The study aim was to investigate LABA add-on effects of tulobuterol patch (TP) and salmeterol inhaler (SA) on pulmonary function, asthma control, and health status. Patients who had adult-onset under-controlled asthma, despite taking inhaled corticosteroids, were enrolled in a randomized, open-label, parallel-group, proof-of-concept study of 12-week add-on treatment with TP (n = 16) or SA (n = 17). Spirometry, impulse oscillometry (IOS), exhaled nitric oxide levels, and clinical questionnaires of asthma control, health status (St. George’s Respiratory Questionnaire: SGRQ), and symptoms were evaluated every 4 weeks. Add-on treatment of SA significantly improved the spirometric indices of small airway obstruction (forced expiratory flow between 25% and 75% of FVC: FEF25-75 , and maximum expiratory flow at 25% of FVC: MEF25 ) and IOS indices of whole respiratory resistance (resistance at 5 Hz) as compared to TP. In intra-group comparisons, add-on treatment of TP improved the scores of the asthma control test and the total SGRQ, as well as the symptom and impact components of the SGRQ. SA add-on treatment improved FEV1 and IOS parameters of resistance at 20 Hz and reactance at 5 Hz. Neither of the treatments improved exhaled nitric oxide levels. In conclusion, add-on treatment of TP improved asthma control and health status, whereas SA improved pulmonary function measures associated with large and small airway involvement among patients with adult-onset mild-to-moderate asthma. This article is protected by copyright. All rights reserved.

PMID: 27718262 [PubMed – as supplied by publisher]

View full post on pubmed: asthma

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Determinants of longitudinal health-related quality of life change in children with asthma from low-income families: a report from the PROMIS(®) Pediatric Asthma Study.

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Determinants of longitudinal health-related quality of life change in children with asthma from low-income families: a report from the PROMIS(®) Pediatric Asthma Study.

Clin Exp Allergy. 2016 Sep 24;

Authors: Li Z, Leite W, Thompson L, Gross HE, Shenkman E, Reeve BB, DeWalt DA, Huang IC

Abstract
BACKGROUND: How the longitudinal asthma control status and other socio-demographic factors influence the changes of health-related quality of life (HRQOL) among asthmatic children, especially from low-income families, has not been fully investigated.
OBJECTIVES: This study aimed to describe the trajectories of asthma-specific HRQOL over 15 months, and examine the effect of asthma control status on HRQOL by taking socio-demographic factors into consideration.
METHODS: 229 dyads of asthmatic children and their parents enrolled in public insurance programs were recruited for assessing asthma control status and HRQOL over 4 time points of assessment. Asthma control status was measured using the Asthma Control and Communication Instrument and asthma-specific HRQOL was assessed using the Patient-Reported Outcomes Measurement Information System’s Pediatric Asthma Impact Scale. Latent growth models (LGMs) were applied to examine the trajectory of HRQOL and the factors contributing to the changes of HRQOL.
RESULTS: Unconditional LGM revealed that HRQOL was improved over time. Conditional LGM suggested that accounting for asthma control and participants’ socio-demographic factors, the variation in the initial level of HRQOL was significant, yet the rate of change was not. Conditional LGM also revealed that poorly-controlled asthma status was associated with poor HRQOL at each time point (p’s<0.05). Lower parental education was associated with lower baseline HRQOL (p<0.05). Hispanic children had a larger increase in HRQOL over time (p<0.01) than non-Hispanic White children.
CONCLUSIONS: Vulnerable socio-demographic characteristics and poorly controlled asthma status affect HRQOL in children. This finding encourages interventions to improve asthma control status and HRQOL in minority children. This article is protected by copyright. All rights reserved.

PMID: 27664979 [PubMed – as supplied by publisher]

View full post on pubmed: asthma