Condition: COPD
Intervention: Other: No intervention
Sponsor: Chinese University of Hong Kong
Recruiting – verified August 2016
View full post on ClinicalTrials.gov: asthma | Studies received in the last 14 days
Media advisory: Buffalo teens with asthma teach each other how to best manage their disease – UB News Center
|
Media advisory: Buffalo teens with asthma teach each other how to best manage their disease
UB News Center The program, called PeerLed Asthma Self-Management for Adolescents (PLASMA), is led by researchers at the University of Rochester School of Nursing in collaboration with the Jacobs School of Medicine and Biomedical Sciences at the University at … |
View full post on asthma – Google News
Camp We-No-Wheeze makes kids smart about their asthma – St. Cloud Times
St. Cloud Times |
Camp We-No-Wheeze makes kids smart about their asthma
St. Cloud Times The 10-year-old St. Cloud girl will attend Camp We-No-Wheeze for the second year, an overnight camp designed specifically for kids with asthma. "It's fun. You get to play games and learn about your asthma," she said. They learn about what can trigger … |
View full post on asthma – Google News
New Apps Teach Kids about Their Health – BU Today
BU Today |
New Apps Teach Kids about Their Health
BU Today Asthma—a chronic disease that causes wheezing, breathlessness, chest tightness, and coughing—affects approximately one in 10 kids in the United States, and that number is on the rise. The disease is the number one cause of pediatric emergency room … |
View full post on asthma – Google News
Most Parents Do Not Understand Their Children’s Asthma Medications, News Study Shows – Nature World News
Nature World News |
Most Parents Do Not Understand Their Children's Asthma Medications, News Study Shows
Nature World News The study, published in the Journal of Allergy and Clinical Immunology, suggests that most of the times, parents do not fully understand their health care provider's instruction for the asthma medication of their children. For the study, researchers … |
View full post on asthma – Google News
Asthma patient urges parents to get their kids checked out for asthma – WREX-TV
WREX-TV |
Asthma patient urges parents to get their kids checked out for asthma
WREX-TV It turns out Susan has allergy induced asthma, which means just about anything could set off an asthma attack. Now she's speaking out and urging parents to get their kids checked out if they notice them coughing or wheezing. "The sooner you diagnose it … |
View full post on asthma – Google News
Yoga could help asthma sufferers get their breath back, Chinese University of Hong Kong reveal – Daily Mail
Daily Mail |
Yoga could help asthma sufferers get their breath back, Chinese University of Hong Kong reveal
Daily Mail Research suggests that the ancient Eastern art eases symptoms of asthma and improves quality of life. It is thought that the breathing exercises and postures relax the muscles in the airways and expand the chest. Plus, calming the mind may cut the odds … Yoga May Have Health Benefits For People With Asthma Yoga can help asthma patients breathe better, says new study Can yoga really help to fight asthma? |
View full post on asthma – Google News
Yoga could help asthma sufferers get their breath back: Exercises found to decrease chance of attacks by relaxing … – Daily Mail
Daily Mail |
Yoga could help asthma sufferers get their breath back: Exercises found to decrease chance of attacks by relaxing …
Daily Mail Research suggests that the ancient Eastern art eases symptoms of asthma and improves quality of life. It is thought that the breathing exercises and postures relax the muscles in the airways and expand the chest. Plus, calming the mind may cut the odds … Yoga May Have Health Benefits For People With Asthma Yoga can help asthma patients breathe better, says new study Can yoga really help to fight asthma? |
View full post on asthma – Google News
A Harvard Startup’s Games Teach Kids How to Care for Their Asthma and Allergies – BostInno
BostInno |
A Harvard Startup's Games Teach Kids How to Care for Their Asthma and Allergies
BostInno Picking up on the need for amusing games focused on teaching children about their own health, local startup Wizdy has already launched its first app geared toward kids with asthma called Wizdy Pets. The venture, whose co-founders have ties to Boston … |
View full post on asthma – Google News
HB-EGF-Promoted Airway Smooth Muscle Cells and Their Progenitor Migration Contribute to Airway Smooth Muscle Remodeling in Asthmatic Mouse.
| Related Articles |
HB-EGF-Promoted Airway Smooth Muscle Cells and Their Progenitor Migration Contribute to Airway Smooth Muscle Remodeling in Asthmatic Mouse.
J Immunol. 2016 Jan 29;
Authors: Wang Q, Li H, Yao Y, Lu G, Wang Y, Xia D, Zhou J
Abstract
The airway smooth muscle (ASM) cells’ proliferation, migration, and their progenitor’s migration are currently regarded as causative factors for ASM remodeling in asthma. Heparin-binding epidermal growth factor (HB-EGF), a potent mitogen and chemotactic factor, could promote ASM cell proliferation through MAPK pathways. In this study, we obtained primary ASM cells and their progenitors from C57BL/6 mice and went on to explore the role of HB-EGF in these cells migration and the underlying mechanisms. We found that recombinant HB-EGF (rHB-EGF) intratracheal instillation accelerated ASM layer thickening in an OVA-induced asthmatic mouse. Modified Boyden chamber assay revealed that rHB-EGF facilitate ASM cell migration in a dose-dependent manner and ASM cells from asthmatic mice had a greater migration ability than that from normal counterparts. rHB-EGF could stimulate the phosphorylation of ERK1/2 and p38 in ASM cells but further migration assay showed that only epidermal growth factor receptor inhibitor (AG1478) or p38 inhibitor (SB203580), but not ERK1/2 inhibitor (PD98059), could inhibit rHB-EGF-mediated ASM cells migration. Actin cytoskeleton experiments exhibited that rHB-EGF could cause actin stress fibers disassembly and focal adhesions formation of ASM cells through the activation of p38. Finally, airway instillation of rHB-EGF promoted the recruitment of bone marrow-derived smooth muscle progenitor cells, which were transferred via caudal vein, migrating into the airway from the circulation. These observations demonstrated that ASM remodeling in asthma might have resulted from HB-EGF-mediated ASM cells and their progenitor cells migration, via p38 MAPK-dependent actin cytoskeleton remodeling.
PMID: 26826248 [PubMed – as supplied by publisher]
View full post on pubmed: asthma