Vitamin D Levels Found To Be Lower Among Asthmatic Adolescents – Lung Disease News


Lung Disease News

Vitamin D Levels Found To Be Lower Among Asthmatic Adolescents
Lung Disease News
According to a recent study led by Ourania Kolokotroni from the Cyprus International Institute for Environmental & Public Health in association with Harvard School of Public Health, Cyprus University of Technology, asthmatic young people have lower

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Vitamin D improves corticosteroid efficacy and attenuates its side-effects in an animal model of asthma.

Vitamin D improves corticosteroid efficacy and attenuates its side-effects in an animal model of asthma.

Can J Physiol Pharmacol. 2014 Nov 3;:1-9

Authors: Mehta AA, Agrawal AD, Appanna V, Chaudagar KK

Abstract
The subacute use of corticosteroids has side-effects such as glucose intolerance, dyslipidemia, anxiety, and depression, which could be halted with vitamin D, which is an immunomodulatory vitamin. Thus, we aimed to study the anti-asthmatic efficacy and side-effects profile of vitamin D, the corticosteroid dexamethasone, and their combination on ovalbumin-induced airway inflammation in rats. For this, 2 different doses of vitamin D (50 IU/kg, daily for 2 weeks, or and 60000 IU/kg, bolus dose, by intraperitoneal injection (i.p.)) were administered in combination with dexamethasone (2.5 mg/kg, i.p., for 2 weeks) prior to challenge with ovalbumin. At the end of the therapy, the asthmatic parameters such as differential white blood cell counts, serum levels of immunoglobulin E, bronchoalveolar lavaged fluid, and interleukin-5, as well as serum levels of nitric oxide were significantly increased after allergen challenges in asthmatic rats as compared with the controls. Such increases were significantly attenuated by monotherapy with vitamin D and with combination therapy of vitamin D and dexamethasone, where the combination therapy was superior to the monotherapy. Dexamethasone-induced hyperglycemia, hyperlipidemia, and behavioral abnormalities in the allergic rats were attenuated with vitamin D. The daily dose was better for controlling serum levels of immunoglobulin E than the bolus dose, whereas the bolus was superior for reducing dexamethasone-induced psychotropic abnormalities. There were no significant changes in other parameters between the daily and the bolus dose. In conclusion, a daily dose of vitamin D in combination with dexamethasone is more efficacious for treating asthma in allergic rats than monotherapy.

PMID: 25429688 [PubMed – as supplied by publisher]

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Low Vitamin D Tied to Asthma Attacks – New York Times (blog)


Medical News Today

Low Vitamin D Tied to Asthma Attacks
New York Times (blog)
Worsening of asthma was indicated by the number of prescriptions for asthma medicine filled and the number of physician visits. The researchers found that during the year before their first vitamin D test, 15 percent of people with readings between 0
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Asthma lets up with vitamin D consumption – helpmeoutDOC News – A consistent flow of medical news


helpmeoutDOC News – A consistent flow of medical news

Asthma lets up with vitamin D consumption
helpmeoutDOC News – A consistent flow of medical news
Vitamin D's influence on asthma has been regarded with skepticism, but Dr. Ronit Confino-Cohen of Tel Aviv University considers Vitamin D able to regulate body's immune responses, reducing asthma's influence over the immune system. “Most of the

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