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Vitamin D deficiency linked to increased risk of asthma attacks – Medical News Today


Medical News Today

Vitamin D deficiency linked to increased risk of asthma attacks
Medical News Today
"Vitamin D has significant immunomodulatory effects and, as such, was believed to have an effect on asthma – an immunologically mediated disease," notes study author Dr. Ronit Confino-Cohen, of the Sackler Faculty of Medicine at Tel Aviv University.
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Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children.

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Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children.

Immunobiology. 2014 Jul 22;

Authors: Hamzaoui A, Berraïes A, Hamdi B, Kaabachi W, Ammar J, Hamzaoui K

Abstract
Vitamin D [25(OH)D3] deficiency has been associated with asthma as in many inflammatory and autoimmune pathologies; however, there is still a lack of data about the effects of administration of vitamin D in immune regulation in young asthmatic patients. In this study, we investigated its inhibitory effect on the immune response in young asthmatic patients and the possible mechanisms involved. Peripheral blood CD4(+) T cells from 10 asthmatic patients and 10 healthy controls were cultured under Th17 polarizing conditions in the presence or absence of [25(OH)D3], IL-17 cytokine production was determined by ELISA and flow cytometry. Messenger RNA (mRNA) expression of several factors related to Th17 cell function was determined by real-time PCR. The effect of [25(OH)D3]-treated dendritic cells (DCs) on CD4(+) T cell response was determined by ELISA and flow cytometry. Stimulation of naive CD4(+) T cells under Th17 polarizing conditions showed a higher Th17 cell differentiation in asthmatic patients than healthy controls. The addition of [25(OH)D3] significantly inhibited Th17 cell differentiation both in patients [P<0.001] and in normal controls [P=0.001] in a dose-dependent way. [25(OH)D3] was able to inhibit the gene expression of RORC, IL-17, IL-23R, and CCR6. [25(OH)D3]-treated DCs significantly inhibited IL-17 production [P=0.002] and decreased the percentage of CD4(+)IL-17(+) [P=0.007] in young asthmatics. The findings suggest that the inhibitory effect of [25(OH)D3] on the Th17 response was mediated via both T cells and DCs. DCs pathway is involved in the direct inhibition of 25(OH)D3 on Th17 cell differentiation in young asthmatics.

PMID: 25128460 [PubMed – as supplied by publisher]

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Does vitamin D help with asthma? More study needed

By Janice Neumann NEW YORK (Reuters Health) – Asthma sufferers who received vitamin D supplements for six months, in addition to their regular inhalers, could breathe a little easier than those who relied only on the inhalers, in a recent study in Iran. The researchers say the results – if confirmed by larger studies – might help the many people who sometimes have troublesome asthma symptoms even though they use medication. “It does build some on the growing amount of data that shows vitamin D might help those affected by asthma,” Dr. Mario Castro, who was not involved in the study, told Reuters Health. “Given that vitamin D is a relatively benign supplement,” the small improvement in lung function “would be worthwhile if it was confirmed with other improvements in asthma control,” he said, such as fewer symptoms or a reduced need for medication.

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