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Invited Commentary: Childhood Acute Lymphoblastic Leukemia and Allergies: Biology or Bias?
Am J Epidemiol. 2012 Nov 20;
Authors: Linabery AM, Spector LG
Abstract
Previous epidemiologic studies have shown an inverse association between a personal history of atopy/allergies, both overall and among asthma, eczema, and hay fever investigated separately, and childhood acute lymphoblastic leukemia (ALL) with some consistency; however, in most of these studies, exposure data were collected by maternal interview. Now, in a population-based and records-based study in this issue of the Journal (Am J Epidemiol. 2012;000(0):000-000), Chang et al. report an increased risk for allergic conditions across different etiologic time periods, calling the former paradigm into doubt. A review of the basic biology literature shows that proposed mechanisms support either a positive or an inverse association. In light of this ambiguity, it is epidemiology’s turn to determine the direction of association.
PMID: 23171875 [PubMed – as supplied by publisher]
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