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Teva's Asthma Drug 'Significantly' Improves Lung Function In Phase 3 Trials
NASDAQ (RTTNews.com) – Teva Pharmaceutical Industries Ltd. ( TEVA ) Monday said asthma patients with elevated eosinophils showed significant improvement in lung function and asthma control after being treated with reslizumab in final-stage studies of the anti … |
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Condition: Asthma
Interventions: Drug: BHT 0.1%; Drug: BHT 0.5%; Drug: Placebo for RMT-B; Drug: Placebo for HFA-MDI
Sponsor: Boehringer Ingelheim
Completed – verified August 2014
View full post on ClinicalTrials.gov: asthma | received in the last 14 days
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Vitamin D supplementation improved airway function in patients with asthma
Healio Patients with asthma who were treated with vitamin D and asthma controllers had significantly improved airway function after 24 weeks compared with patients treated with asthma controllers alone, according to recent study results. Researchers studied … |
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| Related Articles |
Does ?-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of ?-Hexosaminidase in Mast Cell Granules.
J Immunol. 2014 Jul 11;
Authors: Fukuishi N, Murakami S, Ohno A, Yamanaka N, Matsui N, Fukutsuji K, Yamada S, Itoh K, Akagi M
Abstract
?-Hexosaminidase, which is generally present in the lysosome, is essential for glycoprotein metabolism in the maintenance of cell homeostasis. In mast cells (MCs), large amounts of ?-hexosaminidase are present in the granules as opposed to the lysosome, and the biological role of MC ?-hexosaminidase has yet to be fully elucidated. Therefore, we investigated the biological role of ?-hexosaminidase in MC granules. Bone marrow-derived MCs from C57BL/6 (BL/6-BMMC) or ?-hexosaminidase gene-deficient (hexb(-/-)-BMMC) mice were transplanted into MC-deficient (WBB6F1/J-Kit(W)/Kit(W-v) [W/W(v)]) mice to generate MC-reconstituted models. In asthma model experiments, no differences were observed in the symptoms of BL/6, W/W(v), BL/6-BMMC-reconstituted W/W(v), or hexb(-/-)-BMMC-reconstituted W/W(v) mice. In Staphylococcus epidermidis experimental infection model experiments, the severity of symptoms and frequency of death were markedly higher in W/W(v) and hexb(-/-)-BMMC-reconstituted W/W(v) mice than in BL/6 and BL/6-BMMC-reconstituted W/W(v) mice. The growth of S. epidermidis in an in vitro study was clearly inhibited by addition of BL/6-BMMC lysate, but not by addition of hexb(-/-)-BMMC lysate. Moreover, suppression of bacterial proliferation was completely recovered when bacteria were incubated with hexb(-/-)-BMMC lysate plus ?-hexosaminidase. Transmission electron microscopy indicated that the cell wall of S. epidermidis was heavily degraded following coincubation of bacteria with BL/6-BMMC lysate, but not following coincubation with hexb(-/-)-BMMC lysate. These findings strongly suggest that MC granule ?-hexosaminidase is crucial for defense against bacterial invasion, but is not involved in the allergic response. Our results also suggest that the bactericidal mechanism of ?-hexosaminidase involves degradation of bacterial cell wall peptidoglycan.
PMID: 25015817 [PubMed – as supplied by publisher]
View full post on pubmed: asthma
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For pregnant smokers, vitamin C supplements improve lung function of newborn
EurekAlert (press release) At birth, newborn infants born to smokers show decreased pulmonary function test (PFT) results, with respiratory changes leading to increased hospitalization for respiratory infections, and increased incidence of childhood asthma, according to … |
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Roche drug cuts asthma attacks, improves lung function -study
Reuters The biotech drug lebrikizumab, which was developed by Roche Holding's Genentech unit, was tested at three doses in patients whose asthma was not sufficiently controlled even with high-dose, inhaled corticosteroids and a second asthma-controlling … |
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Fat mass not linked to lung function in children with asthma
News-Medical.net They studied 21 girls (mean age 13.6 years) and 27 boys (mean age 11.9 years) with asthma who underwent dual-energy X-ray absorptiometry (DEXA) to measure body composition, as well as spirometry. In boys, there was a significant positive correlation … |
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Drug Discovery & Development |
GSK, Theravance asthma drug shows improved lung function in study
Reuters The drug, already approved in the U.S. to treat chronic obstructive pulmonary disease (COPD) under the brand name Breo, proved more effective than fluticasone furoate alone for patients with moderate to severe asthma at the end of a 12-week treatment … GSK, Theravance Report Positive Results For FF/VI In Late Stage Asthma Study Theravance and Glaxo say asthma study succeeded |
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Improved lung function in patients with moderate asthma severity observed with …
News-Medical.net Boehringer Ingelheim will present a pooled analysis of new data from the Phase 3 UniTinA-asthma® program at the European Respiratory Society (ERS) Annual Congress 2013 in Barcelona. The data from the individual MezzoTinA-asthma® Phase 3 studies … |
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Array Biopharma's asthma drug helps lung function in study
Denver Post Boulder-based Array Biopharma Inc. said one of its drugs met the main goal of improving lung function in a mid-stage study among patients with mild to moderate persistent allergic asthma. Array shares rose 10.4 percent Tuesday, to close at $6.14 after … Array Seeks Asthma Drug Partner Following Mid-Stage Study Results Array Shares Climb After Asthma Drug Shows Positive Phase 2 Results Array BioPharma: ARRY-502 Meets Primary And Secondary Endpoints In … |
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