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Array says asthma drug improves lung function in study, seeks partner for …
MedCity News (Reuters) – Array Biopharma Inc said one of its drugs met the main goal of improving lung function in a mid-stage study among patients with mild to moderate persistent allergic asthma. Array shares rose as much as 19 percent to $6.64 — their highest … |
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Array Biopharma's new asthma drug meets goal of improved lung function
Denver Post Array Biopharma Inc. said Tuesday, one of its drugs met the main goal of improving lung function in a mid-stage study among patients with mild to moderate persistent allergic asthma. Array shares rose 12.7 percent, or 71 cents, to $6.27 in morning … Array BioPharma: Study Shows Asthma Candidate ARRY-502 Improves Lung … Array BioPharma scores midstage success for asthma drug Array Shares Climb After Asthma Drug Shows Positive Phase 2 Results |
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Differences in serial lung function recorded on four data-logging meters.
J Asthma. 2013 Jul 19;
Authors: Adeniyi BO, Moore CV, Erhabor GE, Burge S
Abstract
Abstract Introduction Lung function measurements performed several times daily are useful for the diagnosis of occupational asthma. Patient fabrication of hand-recorded charts can limit confidence in the results; this is overcome using electronic meters that log time and measurement. We have compared individual and meter differences in FEV1 and PEF recorded by hand and from meter logs using expert subjects on 4 data-logging spirometers with different methods of measurement and different quality control software. Method Eight workers in a respiratory physiology department were asked to record FEV1 and PEF 2-hourly from waking for 7 days using 4 electronic meters (Easyone, Micro DL, Vitalograph Diary card 2110 and Piko-1) in random order. Subjects hand-recorded the best FEV1 and PEF from each session, this was compared with the logged data. Results Discordant measurements from individuals were lower for FEV1 than PEF and differed from 4.4-19.1% for FEV1 (mean 9.4%, p<0.0001) and 6-23.3% for PEF (mean 12.6, p<0.0001). There were also significant differences between meters for both variables (p<0.0001). The magnitude of the differences in PEF was highest for the Easyone (34 litres/min) and lowest for the Vitalograph Diary card 2110 (14 litres/min) and varied significantly between meters (mean 22 L/min, p=0.002). Conclusion Differences between hand-recorded and logged measurements are unlikely to be due solely to patient fabrication and can be due to quality criteria or other unclear software requirements applied after the results are shown on the meter screen; they differ between meters. Whether the differences shown affect clinical outcome will require further investigation.
PMID: 23865815 [PubMed – as supplied by publisher]
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Using Asthma Medication, Scientists Improve Cognitive Function in Mouse …
Medical Daily New research at the Stanford University School of Medicine found that an existing, FDA-approved form of asthma medication called formoterol improved cognitive functions in a mouse model of Down syndrome. Science Daily reports that by activating certain … |
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SHP-1 Regulation of Mast Cell Function in Allergic Inflammation and Anaphylaxis.
PLoS One. 2013;8(2):e55763
Authors: Zhou L, Oh SY, Zhou Y, Yuan B, Wu F, Oh MH, Wang Y, Takemoto C, Van Rooijen N, Zheng T, Zhu Z
Abstract
Allergic inflammation and severe allergic reactions (anaphylaxis) are important in allergen induced diseases. Bacterial products such as lipopolysaccharide (LPS) are ubiquitous and can facilitate allergen induced Th2 immune responses. Phosphatase SHP-1 is critical in regulating immunological homeostasis and in allergen induced Th2 immune responses in the lung. However, the mechanisms underlying the initiation of allergic inflammation and allergen induced anaphylaxis are still not completely elucidated and it is unclear whether SHP-1 plays any role in LPS-induced airway inflammation and in allergen-induced anaphylaxis. In this study we tested the hypothesis that phosphatase SHP-1 plays an important role in allergic inflammation and anaphylaxis and determined whether its effects are through regulation of mast cell functions. SHP-1 deficient (mev/+ and mev/mev) and mast cell deficient (Kit(W-sh)) mice were examined in their responses to LPS airway stimulation and to ovalbumin (OVA) allergen induced systemic anaphylaxis. Compared to wild type mice, mev/+ mice had significantly enhanced LPS induced airway inflammation and OVA induced anaphylactic responses, including hypothermia and clinical symptoms. These changes were mast cell dependent as Kit(W-sh) mice had reduced responses whereas adoptive transfer of mast cells restored the responses. However, T and B cells were not involved and macrophages did not play a significant role in LPS induced airway inflammation. Interestingly, basophil differentiation from SHP-1 deficient bone marrow cells was significantly reduced. These findings provided evidence that through regulation of mast cell functions SHP-1 plays a critical role as a negative regulator in allergic inflammation and in allergen induced anaphylaxis. In addition, SHP-1 seems to be required for normal basophil development.
PMID: 23390550 [PubMed – in process]
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Vitamin D Deficiency And Lung Function In Asthmatic Children
Medical News Today A new study from researchers in Boston has found that poorer lung function in asthmatic children, treated with inhaled corticosteroids, is linked with vitamin D deficiency.Ann Che. Vitamin D deficiency may impair lung function in asthmatic children treated … Vitamin D Deficiency Linked to Poorer Lung Function in Children |
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Vitamin D deficiency may impair lung function in asthmatic children treated …
News-Medical.net Vitamin D deficiency is associated with poorer lung function in asthmatic children treated with inhaled corticosteroids, according to a new study from researchers in Boston. Vitamin D Deficiency Linked to Poorer Lung Function in Children |
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Vitamin D Deficiency Associated with Poor Lung Function in Asthmatic Children
news Stories The deficiency was associated with poorer lung function in asthmatic children treated with inhaled corticosteroids. |
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Vitamin D Deficiency and Lung Function in Asthmatic Children
Newswise (press release) Vitamin D deficiency is associated with poorer lung function in asthmatic children treated with inhaled corticosteroids, according to a new study from researchers in Boston. |
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Vitamin D deficiency and poorer lung function in asthmatic children treated …
Medical Xpress Vitamin D deficiency is associated with poorer lung function in asthmatic children treated with inhaled corticosteroids, according to a new study from researchers in Boston. |
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